L’équipe ICS-Neuro développe et applique des méthodes d’imagerie chimique dans le domaine des neurosciences pour comprendre les fonctions neurophysiologiques des métaux et les effets neurotoxiques de contaminants inorganiques stables ou radioactifs.
The ICS-Neuro team develops and applies chemical imaging methods in the field of neuroscience to understand the neurophysiological functions of metals and the neurotoxic effects of stable or radioactive inorganic contaminants.
The main research themes of the ICS-Neuro team are:
- Neurobiology of copper and zinc
- Metals neurotoxicology
- Iron and copper dyshomeostasis in neurodegenerative diseases
RESPONSABLE / HEAD
Asuncion Carmona
Permanent / Permanent reseacher
Richard Ortega
CDD chercheur / Postdoc
Léa Normand
Doctorant / PhD student
Raffy Caneda
Inès Kelkoul
CDD ingénieur / Engineer
Lina Sikouk
Thomas Tilloloy
Storage and transport of labile iron is mediated by lysosomes in axons and dendrites of hippocampal neurons. Kittilukkana A, Carmona A, Normand L, Gibout C, Somogyi A, Pilapong C, Ortega R. (2025) Metallomics, 17(7), mfaf021 https://doi.org/10.1093/mtomcs/mfaf021
Neurotoxicology of Metals and Metalloids Richard Ortega, Asuncion Carmona Encyclopedia of the Neurological Sciences (Third Edition), 2025, Pages 644-656 https://doi.org/10.1016/B978-0-323-95702-1.00468-1
Synchrotron-based correlative imaging of metals and proteins in neuronal cells: state of the art and future challenges in neurometallomics Ines Kelkoul, Virginia Puente Muñoz, Richard Ortega, Asuncion Carmona Metallomics, Volume 17, Issue 2, February 2025, mfaf003, https://doi.org/10.1093/mtomcs/mfaf003
Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model Abdeen, A.H., Trist, B.G., Nikseresht, S. et al. Acta Neuropathologica 149, 22 (2025). https://doi.org/10.1007/s00401-025-02859-6
Impaired maturation of wild-type superoxide dismutase 1 associated with neurodegeneration in Parkinson disease brain and a novel murine model Amr H. Abdeen, Benjamin G. Trist, Sara Nikseresht, Richard Harwood, Stephane Roudeau, Benjamin D. Rowlands, Fabian Kreilaus, Veronica Cottam, David Mor, Miriam Richardson, Joel Siciliano, Julia Forkgen, Greta Schaffer, Sian Genoud, Anne A. Li, Nicholas Proschogo, Bernadeth Antonio, Gerald Falkenberg, Dennis Brueckner, Kai Kysenius, Jeffrey R. Liddell, Sandrine Chan Moi Fat, Sharlynn Wu, Jennifier Fifita, Thomas E. Lockwood, David P. Bishop, Ian Blair, Richard Ortega, Peter J. Crouch, Kay L. Double
Native Cryo-Correlative Light and Synchrotron X-ray Fluorescence Imaging of Proteins and Essential Metals in Subcellular Neuronal Compartments Richard Ortega, Mónica Fernández-Monreal, Noémie Pied, Stéphane Roudeau, Peter Cloetens, Asuncion Carmona Chemical & Biomedical Imaging 2024, 2, 11, 744–754.
Native cryo-correlative light and synchrotron X-ray fluorescence imaging of proteins and essential metals in developing neurons. Ortega R, Fernandez Monreal M, Pied N, Roudeau S, Cloetens P, Carmona A. ChemRxiv. (2024)
Metal dyshomeostasis in the substantia nigra of patients with Parkinson’s disease or multiple sclerosis. Carmona A, Carboni E, Gomes LC, Roudeau S, Maass F, Lenz C, Ortega R, Lingor P. Journal of Neurochemistry, 168(2):128-141. (2024)
TauSTED super-resolution imaging of labile iron in primary hippocampal neurons. Kittilukkana A., Carmona A., Pilapong C., Ortega R. Metallomics, 16, mfad074. (2024)
Raffy CANEDA - in progress
Convergence of zinc homeostasis and PCP signaling during axon formation and its initial segment
par Ines KELKOUL - in progress
Cryo-correlative nano-imaging of metals and proteins using synchrotron radiation: applications in neuroscience